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Elevated superoxide generated from dysfunctional mitochondria promotes the formation of excessive H 2 O 2 , the substrate for MPO-mediated hypochlorous acid synthesis and the generation of the inflammatory biomarker, 3-CT

The key preclinical data urgently needed before clinical trials can commence include: (i) efficacy and immune-profiling data derived strictly from clinically relevant orthotopic and spontaneous pulmonary metastasis models, rather than simple ectopic subcutaneous models

What matters is what is bundled around it: who is supervising your protocol, where the medication came from, whether anyone is following up after the cycle

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