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Srensen
Neutrophilia causes excessive ROS production that aggravates the host immunopathological response, leading to a more severe disease (Laforge et al., 2020)
For instance, TfR1 mediates cellular iron uptake, and its upregulation increases iron acquisition, thereby exacerbating ferroptosis
The honest summary is that long-term human safety data is missing and the angiogenesis mechanism is an unresolved theoretical concern
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