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In a notable phase II clinical trial published in The Lancet (2008), Tesofensine demonstrated dose-dependent weight loss of up to 10.6% over 24 weeks in obese individualssubstantially higher than placebo or many existing weight-loss drugs
Metabolism 60:10011011
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A reversed-U dose-response, where less works better than more, is the opposite of the more is stronger instinct a vial of research chemical sells on, and it is exactly the kind of inconvenient texture that only shows up when a compound is actually put through controlled trials
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