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Proposed Mechanisms (Preclinical) IGF-1 Receptor & Downstream Signaling Binds to the IGF-1 receptor (IGF-1R) on target cells
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The breadth of documented activity reflects what the original investigators have described as systems-level pharmacology: rather than acting through a single high-affinity receptor, BPC-157 appears to modulate multiple intersecting cellular pathways including nitric oxide signalling, growth-factor receptor expression, dopamine and serotonin metabolism, and angiogenic vessel formation
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