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Lower doses are generally well-tolerated

When additional therapy is required, NICE recommends considering a GLP-1 receptor agonist (such as Rybelsus) if the patient has a BMI of 35 kg/m or higher (or 32.5 kg/m or higher for people of South Asian or related ethnicity) and specific psychological or medical problems associated with obesity, or if BMI is lower but insulin therapy would have significant occupational implications or weight loss would benefit other obesity-related comorbidities

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Clinical Evidence Behind Semaglutide Semaglutide has the strongest randomized-trial evidence base of any GLP-1 receptor agonist