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It received FDA approval in 2014 for type 2 diabetes, and in 2020 an additional indication was added to reduce major adverse cardiovascular events in adults with type 2 diabetes
models suggest a nearly 700% increase in youth with type 2 diabetes
Anti-PD-1 antibodies such as pembrolizumab and nivolumab were included the second set of antibodies to be approved for the treatment of human malignancies, followed by anti-PD-L1 antibodies such as atezolizumab, durvalumab, and avelumab 86
Furthermore, their differing mechanisms may complicate their effects on blood glucose and cardiovascular health
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