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In initial studies with healthy subjects, weight loss of 5.4 kg was observed after 4 weeks, with gastrointestinal events being the most common side effects ( The addition of other active ingredients such as oral GLP-1 analogues and experimental combination therapies is currently being investigated and is expected to improve efficacy, ease of use, and accessibility in the coming years ( Comparative efficacy and real-world observations In randomized controlled trials, semaglutide, tirzepatide, and retatrutide consistently result in double-digit percentage total weight loss, significantly outperforming previous obesity pharmacotherapy
The oral formulation uses similar delayed release technology
This effect is intentional and evidence-based, supported by multiple clinical trials demonstrating its safety and efficacy
2013 Oct;172(10):1321-6
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