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A metal complex has a sequence, a purity, and a stoichiometry, and material sold at a nominal one-to-one ratio can in practice carry excess free ligand or, worse, excess uncomplexed copper

Formulary decisions can be made on clinical and net-cost grounds without a competing revenue motive

That's the current regulatory calendar

In total, 12 trials from SMART-C were assessed, with the analysis cohort restricted to trials exclusively enrolling participants with diabetes, and participants with diabetes enrolled in the following heart failure and chronic kidney disease trials: DAPA-CKD, EMPA-KIDNEY, DAPA-HF, EMPEROR-Reduced, EMPEROR-Preserved, and DELIVER