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Patients with hypothyroidism may experience changes in their levothyroxine requirements as weight decreases, necessitating dose adjustments monitored by their physician

Tirzepatide (Mounjaro for diabetes and Zepbound for obesity, both Eli Lilly), a dual GLP-1/GIP agonist titrated gradually across a broad dosing range, showed a favorable safety profile, with GIP agonism probably buffering GLP-1-mediated fluid shifts, stabilizing vascular tone and reducing ischemic vulnerability

You can still get food poisoning, gastroenteritis, stress induced diarrhea, and appendicitis while on these medications

Even mild shifts in blood sugar levels can contribute to feeling tired, lightheaded or less alert