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doi: 10.1038/s41421-022-00495-y 457 WuS.SongR.LiuT.LiC

Oral formulations of GLP-1 agonists, including oral semaglutide and oral tirzepatide , create different pharmacokinetic profiles than injections

This heightened response isn't inherently dangerous but requires dose adjustments and closer monitoring than either medication alone

In the presence of oxidative stress or specific electrophilic stimuli , critical cysteine residues on KEAP1 undergo modifications that disrupt KEAP1-mediated repression, resulting in the stabilization and release of Nrf2

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