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Additionally, vitamin B-12 has been shown to improve mood and reduce symptoms of depression
Over 26 weeks, including a dose-escalation period of up to 6 weeks, researchers observed mean percentage weight reductions of 6.0% to 10.8% across the cagrilintide dose groups compared to just 3.0% with placebo
These findings are similar to data recently published by us in clinical cohorts, with E4 carriers exhibiting relatively higher SCAs and lower LCAs with AD even at the pre-clinical stages compared to controls and other APOE genotypes (Huguenard et al., 2022)
These metabolic effects occur through the growth hormone/IGF-1 axis, which plays a central role in regulating lipid metabolism and energy homeostasis
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