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Semaglutide and liraglutide include a fatty acid side chain (acylation) that allows them to bind to albumin in the blood, significantly prolonging their half-life
Ang II activates AT1 receptors, which can lead to various effects on vascular cells, including vasoconstriction, cell growth, and the induction of pro-inflammatory cytokines, as well as pro-fibrogenic actions (Silva-Velasco et al., 2024)
GLP-1 engagement stays lower but continues climbing through the approved range, so each higher step can still change appetite and tolerability
Ultimately, whether or not BPC-157 is worth the risk depends on your personal goalsand your tolerance for regulatory ambiguity
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