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Two key players, PUF-8 and GLD-1, regulate this decision with distinct mechanisms
Kidney protection Semaglutide helps protect the kidneys in people with type 2 diabetes and kidney disease by slowing down kidney function decline and reducing the risk of serious kidney problems
Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis "Among participants with obesity and knee osteoarthritis with moderate-to-severe pain, treatment with once-weekly injectable semaglutide resulted in significantly greater reductions in body weight and pain related to knee osteoarthritis than placebo." nejm.org/doi/full/10.10 Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis "Among participants with obesity and knee osteoarthritis with moderate-to-severe pain, treatment with once-weekly injectable semaglutide resulted in significantly greater reductions in body weight and pain related to knee osteoarthritis than placebo." nejm.org/doi/full/10.10 the question is does it work on non-obese osteoarthritis sufferers Yes, but wouldn't lifestyle intervention with comparable weight loss result in a similar reduction in knee pain
