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In controlled human malaria infection (CHMI) experiments, a sustained increase in circulating G-MDSC was found in volunteers who developed Plasmodium falciparum parasitemia, which suppressed the proliferation of CD4 + and CD8 + T cells and led to a decrease of lymphocytes, interfering with the production of immune memory against the parasite and suppressing the bodys immune response (256)
Mendsaikhan, A., Tooyama, I
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