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Furthermore, we found that GHK-Cu could inhibit RORt expression in the colon tissue of UC mice

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therefore, platelet activation is tightly regulated by inhibitory and regulatory receptors that act as endogenous checkpoints, helping to prevent inappropriate activation and maintain hemostatic balance ( 2+ mobilization and integrin activation, inhibitory receptors act by mechanisms such as cyclic nucleotide elevation (cAMP, and cGMP) and immunoreceptor tyrosine-based inhibition motif (ITIM)-mediated phosphatase recruitment to suppress pro-aggregatory signaling (Scridon, 2022)