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1 Introduction Fibrosis is characterized by the destruction of fibrous connective tissue, activation and proliferation of fibroblasts, elevated collagen fiber secretion, and excessive deposition of extracellular matrix (ECM) (Zhang and Zhang, 2020)

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Metformin is associated with higher relative abundance of mucin-degrading akkermansia muciniphila and several short-chain fatty acid-producing microbiota in the gut

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