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The syringe materials (typically polypropylene or cyclic olefin polymer) may interact differently with the peptide than glass, and the air-liquid interface in a pre-filled syringe is less favorable than in a properly filled vial

For patients on lower injection doses, 0.25mg, 0.5mg, 1mg, or 1.7mg, no confirmed direct-switch protocol exists

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Patients with hypothyroidism secondary to Hashimoto's often struggle with weight gain and metabolic dysfunction despite adequate thyroid hormone replacement