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GLP-1 medications can produce a 10-20% body weight reduction in many patients (ref), which can reduce the excess tissue mass that collapses the airway and causes OSA
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More than additive effects, bupropion combined with naltrexone produces synergistic effect in reducing body weight [18]
Figure 1 4 Clinical evidence of GLP-1R agonists in managing DPN Unlike preclinical evidence, studies investigating the effect of GLP-1R on DPN are quite rare
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