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McDowell LR, Wilkinson N, Madison R, Felix T
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New @Nature A quintuple [GLP-1 + 4 other] receptor agonist drug that exceeds effects of the dual receptor (GLP-1 and GIP, tirzepatide) in the experimental model vs diabetes and obesity (in case you thought a dual receptor was max effect, as also seen with retatrutide, a triple receptor agonist) nature.com/articles/s4158 New @Nature A quintuple [GLP-1 + 4 other] receptor agonist drug that exceeds effects of the dual receptor (GLP-1 and GIP, tirzepatide) in the experimental model vs diabetes and obesity (in case you thought a dual receptor was max effect, as also seen with retatrutide, a triple receptor agonist) nature.com/articles/s4158 A different quintuple receptor agonist will be presented at ADA (GLP-1/GIP/glucagon/amylin/calcitonin) if it is designed to be quintuple agonist, I wonder how many more it hits off-target
The peptide stacking guide on SeekPeptides covers these combinations in detail, though any stacking decisions should be made with medical guidance
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