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Studies show the depth and percentage of microneedle penetration correlate with application forces, which influence the extent of enhancement in skin permeability of GHK-Cu
Topical application places the peptide directly at the target tissue at therapeutic concentrations
The dose escalation protocol successfully minimized these effects compared to immediate high-dose administration
The clinical decision is which molecule does the most work for a given skin presentation, and how to sequence it within the broader skincare routine
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