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In addition, loss of glutathione peroxidase 4 (GPX4), a central regulator of ferroptosis, leads to hemolytic anemia and increases spleen erythroid progenitor death through receptor-interacting protein 3 (RIP3)-dependent necroptosis signaling 48

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Fontana et al (58) revealed that under identical high-fat diet (HFD) conditions, aged mice exhibit exacerbated hepatocellular injury and inflammatory responses compared with young controls

The kinetic data were analyzed by using the GraphPad Prism software with a simple pseudo first-order reaction model to estimate the apparent kinetic parameters