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Clinical Studies and Results Clinical trials have shown that once-weekly dosing of subcutaneous semaglutide at a dose of 2.4 mg led to significant weight loss as compared to placebo, with average reductions of 14.9% from baseline weight or 15.3 kg over the course of 68 weeks

Estrogen receptors in these same brain regions modulate GLP-1 receptor sensitivity

Theres no specific contraindication, but your kidney function needs to be monitored more closely

The median follow-up duration was 1 year (IQR: 0.52 years), with key findings including a median weight loss of 11.7 kg and a median BMI at the most recent follow-up of 31.2 kg/m 2 , reflecting a median reduction of 3.7 kg/m 2