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Women who should avoid PT-141 or only use it under close medical supervision include those with: Uncontrolled hypertension Significant cardiovascular disease Known hypersensitivity to melanocortin peptides A history of severe adverse reactions to injectable therapies Pregnancy or breastfeeding PT-141 can cause temporary increases in blood pressure shortly after administration, which is why cardiovascular screening is an important part of the evaluation process

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Karp NA, Meehan TF, Morgan H, Mason JC, Blake A, Kurbatova N, Smedley D, Jacobsen J, Mott RF, Iyer VJPB