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The authors recommend providing in-depth counselling and possibly slower titration of GLP-1 RAs during initiation in these groups, particularly those who are known to have discontinued metformin previously, in order to decrease discontinuation rates
It also inhibits the production of melanin
======================= Chronic daily headache - Secondary causes Primary chronic headaches of long duration include chronic migraine, chronic tension-type headache, new daily persistent headache, and hemicrania continua
One-time prescribing has less value when tolerability and refill timing remain unresolved
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