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Although many such models describe the physicochemical attributes of P-gp interaction and are shown to have high predictability, existence of multiple binding sites and other complicating factors has prevented the development of a definitive SAR (Stouch and Gudmundsson 2002)
It binds metals and other toxins and transforms them into compounds that can be excreted in bile or urine
Oxidative stress in the pathogenesis of skin disease
In conclusion, the present study is the first systematic report evaluating the pharmacokinetics, tissue distribution, metabolism, and excretion of BPC157
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