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doi: 10.3389/fcell.2020.615461 Received 09 October 2020 Accepted 07 December 2020 Published 05 January 2021 Volume 8 - 2020 Edited by Kiyoung Kim, Soonchunhyang University, South Korea Reviewed by Yanggang Yuan, Nanjing Medical University, China

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In vitro pharmacology (EC 50 ) Evaluation of the agonist activity of compounds 1 23 at the mouse GLP-1 receptor endogenously expressed in TC6 cells, was determined by measuring their effects on cAMP production using the HTRF detection method (performed by Cerep S.A., catalogue 2015, ref