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Biochemical pharmacology

This expands access and makes treatment more convenient for people who prefer not to use injectables

At the adipose tissue level, the combined GIP and GLP-1 agonism reduces M1 macrophage infiltration and pro-inflammatory cytokines such as leptin, increases adiponectin, and enhances insulin sensitivity, thereby improving adipocyte dysfunction.39 GIP additionally increases the storage capacity of adipose tissue, which lowers the likelihood of ectopic fat deposition and reduces the extent of visceral fat.1,5,39 Furthermore, it has demonstrated neuroprotective effects and promotes bone formation1 (Table 2)

However, they said more research is needed to better understand why GLP-1 drugs might help sleep apnea patients, and to track the potential longer-term benefits