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The key is balancing enthusiasm for innovation with commitment to evidence-based practice and patient safety
Infants of B12-deficient mothers can develop deficiency within the first two to three months of life, presenting with poor feeding, irritability, and developmental slowness
People with pernicious anemia may need monthly injections for life
In summary, there remain three bottlenecks for clinical breakthroughs, as follows, the low bioavailability of natural products should be improved, the combined application of two or more compounds should be investigated for more prominent pharmacological effects and the evidence of clinical efficacy of other compounds requiring further confirmation
