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Since fibrosis is the most compelling predictor of outcomes, current and future therapies must focus on improving fibrosis by indirectly reducing pro-fibrotic inflammatory signaling or directly abrogating fibrosis
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Helicobacter pylori is a common bacterium that colonizes gastric mucosa and causes severe gastrointestinal issues in the gut (70)
The pattern of side effects in long-term use shows that gastrointestinal symptoms are most prominent during the first 6 months, particularly during dose escalation
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