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GSH is manufactured in the cytosol by a two-step process: the first step, which combines cysteine and glutamate, is catalyzed by -glutamylcysteine synthetase (GCS)

10.1161/01.HYP.0000130484.20501.df Hypertension

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Furthermore, while the efficacy of these synthetic drugs is remarkably high, the burden of gastrointestinal adverse events remains a challenge that requires carefully monitored dose escalation