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Along this line, a recent meta-analysis of 11 heterogeneous observational studies primarily consisting of pharmacovigilance and cohort studies reported no significant difference in suicidal outcomes between GLP-1 RAs compared with other anti-hyperglycemic drugs (RR:0.568, 95% Cl:0.077-4.205) [27]

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Paradoxically, a recent interesting event was found that direct treatment with specific lipid peroxides (e.g., 4-HNE) at physiological concentrations inhibited the NLRP3 activation and macrophage pyroptosis [129]