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Glucagon-like Peptide-1 Receptor Agonists and Ischaemic Heart Disease Ischaemic heart disease is a major risk factor for HF (both HFrEF and HFpEF)

Additionally, variations in genes encoding glutathione synthesis enzymes (GCLC, GCLM) can reduce baseline GSH production, though these are less common

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Analogous to the BBB, the BRB has an inner component (iBRB) of retinal endothelial cells and an outer component (oBRB) formed by tight junctions between retinal pigment epithelial (RPE) cells [34]

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