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Studies showing increased diagnoses shortly after medication initiation are biologically inconsistent with de novo carcinogenesis and instead suggest detection of pre-existing disease through increased surveillance
According to NICE guideline NG28 on type 2 diabetes management and the specific NICE Technology Appraisal for tirzepatide, GLP-1 receptor agonists like Mounjaro may be considered as part of a comprehensive treatment strategy when glycaemic targets are not achieved with other therapies or when weight loss would provide significant clinical benefit
Approved weight-management options may be more appropriate while retatrutide remains investigational
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