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13 Two meta-analyses of other GLP-1 RA CVOTs found that GLP-1 RAs were associated with greater rates of DR progression, but both studies found that the effect was driven by the extent of hemoglobin A1c reduction, rather than the medications themselves
Clinicians should educate patients about expected gastrointestinal effects during initiation, emphasizing that mild nausea and fullness typically improve within 48 weeks
COAs are published on our COA page rather than supplied only on request, because purity should be documented, not asserted
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