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In hindlimb ischemia models, the peptide accelerates blood flow recovery as measured by laser Doppler scanning, with histological analysis confirming increased vessel numbers and enhanced vascular expression of VEGFR2

A more conservative approach may help reduce unnecessary exposure while allowing someone to assess tolerance and possible benefit

GGT transfers the -glutamyl residue of glutathione to amino acid acceptors (the best acceptor being cystine), releasing -glutamyl peptides and cysteinyl glycine

They also carry the risks inherent to any surgical procedure, require recovery time, and demand lifelong nutritional follow-up