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The peptide backbone provides three coordination sites for copper: the free alpha-amino group of glycine, the deprotonated amide nitrogen of the glycyl-histidyl bond, and the imidazole nitrogen of the histidine side chain, with the lysine epsilon-amine remaining available for further interactions

CJC-1295 Without DAC GHRH Receptor Pathway CJC-1295 without DAC interacts with the GHRH receptor (GHRHR), a class B G protein-coupled receptor that activates the Gs/adenylate cyclase pathway, increasing intracellular cAMP and engaging PKA-linked phosphorylation events