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In APP/PS1 transgenic mice, (D-Ser2)Oxm, a dual GLP-1 and Gcg receptor agonist, notably improves spatial memory and synaptic plasticity, reduces A plaque deposition in the hippocampus, and modulates the PI3K/AKT1/GSK3 signaling pathway [84]
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[63] They were examining hormones secreted during eating, and testing them on pig pancreases, leading to the discovery of GLP-1's significant effects in 1988
Increasing global obesity prevalence heightens the need for effective pharmacological interventions that can address weight gain, metabolic dysfunction and the progression of obesity-related chronic diseases
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