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At clinical doses under supervision, the most common side effects are mild nausea in the first week (typically resolves by day 7 to 10), injection site reactions (redness, minor swelling, localized soreness lasting 24 hours), and occasional transient fatigue or mild headache in the first few days
It has the molecular formula C 78 H 123 N 23 O 23 S 2 , a molecular weight of 1,815.1 g/mol, and CAS number 221231-10-3, and contains an intramolecular disulfide bridge that constrains its conformation
Problems such as SIBO, altered intestinal microbiota, and delayed gastric emptying have added to the difficulties of oral therapy in PD, often culminating in commonly observed motor fluctuations such as delayed on or early-morning off sometimes associated with severe non-motor symptoms as well
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