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As a transcriptional suppressor, Hes1 in the retina inhibits the differentiation of specific cell types and leads to excessive gliosis, increased inflammatory cytokine release, and ECM imbalance

Uniform manifold approximation and projection (UMAP) visualization showed that liraglutide treatment shifted the -1 subcluster toward the -1 subcluster compared with control (Figure 4D, dotted arrow)

Immunofluorescence staining was performed on the frozen cochlear cryosections of P3, P14, and P30 C57BL/6 mouse cochleae (Figure 1A), and Tuj 1, a neuron-specific marker which specifically labels both the cytoplasm and neurite of SGN, was used to mark SGN

[6] Secondly, the gastrointestinal effects of Wegovy may indirectly impact sleep quality