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Description

Under unfolded protein stress conditions, GRP78 binds to unfolded or misfolded proteins and subsequently activates downstream ER stress sensors, including IRE1, PERK, and ATF6, to trigger a response to unfolded proteins (Yoboue et al., 2017) , (Wei et al., 2012)

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These programmes typically involve dietary modification with a caloric deficit of 500-600 kcal per day, increased physical activity with a target of 150-300 minutes of moderate-intensity exercise weekly, and behavioural support to address eating patterns and psychological factors

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