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Consequently, there is clearly an urgent need for a drug combination with multiple pharmacological activities against AS so as to achieve synergistic anti-AS efficacy [3]

That means nasal dosing often needs to consider a slightly higher dose (or more frequent spritz) to match systemic exposure from injection

Both drugs showed similar inhibition efficiency on COX activity, but the naproxen group experienced more ulcers, particularly larger ones, compared to the ATB-346 group

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