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The mean age was 64 years and 8% of patients were 75 years of age or older
There are other, perhaps more common, genetic variants associated with the risk of developing ADincluding the late onset form of the disease (LOAD)such as ApoE4 [521, 522] or those identified more recently (e.g., mutations in CD36 [523], see [524] for review)
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Consequently, loss of FMRP results in an aberrantly increased mGluRI expression in these neurons, leading to enhanced mGluR-related long-term depression causing cognitive impairments and intellectual disability
