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DHEA induces 11-HSD2 by acting on CCAAT/enhancer-binding proteins. Journal of the American Society of Nephrology

These changes were paralleled by marked decreases in total, abdominal, leg, and arm fat percentage, along with increases in FFM and total body muscle percentage

In fact AR231453, a selective GPR119 agonist, improves glucose tolerance and insulin sensitivity in both WT and Gpr119 cell / , suggesting how insulin release is independent from pancreatic GPR119 but depends on gut incretin release (330)

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