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Currently approved and commonly used GLP-1R agonists include exenatide (the synthetic form of Ex-4, a naturally occurring GLP-1R agonist), lixisenatide, dulaglutide liraglutide and semaglutide ( Figure 2 ) (17, 110)
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An inducer of NLRP3 activation is the disassociation of thioredoxin-interacting protein (TXNIP), an intracellular redox regulator that inhibits antioxidants, from TRX (thioredoxin), a redox protein, via ROS or oxidative stress (122, 124)
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