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It is produced in response to metabolic stress and plays a key role in modulating cellular energy use , insulin response, and metabolic homeostasis
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The first glimpse of the full-length KAR structure was a relatively low-resolution, 7.6- reconstruction of homomeric GluK2 in the high-affinity agonist (2S, 4R)-4-methylglutamate (SYM 2081)-bound non-conducting state (Meyerson et al., 2014), which was followed by a similar successor structure with improved 3.8- resolution (Meyerson et al., 2016)
Certain metabolic disorders
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