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Preclinical evidence supports the role of GLP-1RAs in alleviating neuropathic pain through the modulation of microglial activity, inflammatory cytokine production and -endorphin release [63, 65, 68, 70,71,72,73,74]
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Brand-name tirzepatide has been tested for its safety, efficacy, and quality in clinical trials and is available in fixed doses only
Taken together, these results suggest that CPP-CAND inhibited the FOXO4-p53 interaction in the nucleus, which enabled the extranuclear transport of p53 and selectively induced apoptosis in senescent cells
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