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GSH exists in two interconvertible forms: the biologically active reduced form (GSH) and the oxidised disulfide form (GSSG), in which two GSH molecules are joined at their sulfur atoms
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In human breast cancer cell lines, lucanthone, an inhibitor of topoisomerase II and APE1 endonuclease, has been demonstrated to enhance the cytotoxic action of alkylating drugs [113]
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