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(2006) characterized TREK-1 knockout mice and observed resistance to behavioral despair paradigms, elevated serotonin levels, and increased hippocampal neurogenesis, establishing the rationale for TREK-1 blockade [3]

A 2026 UK review of the standardised EGb 761 extract, the decisive Laws 2012 meta-analysis showing no effect in healthy adults, the null GEM and GuidAge prevention trials, the modest 240 mg benefit in mild dementia, dosing and the bleeding risk versus Dihexas unproven HGF/c-Met synaptogenesis and the c-Met concern