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Medical conditions that reduce response Several conditions can blunt semaglutide effectiveness regardless of whether it is compounded or brand-name: Hypothyroidism , especially untreated or undertreated, slows metabolism and counteracts weight loss Insulin resistance and type 2 diabetes can require higher doses for the same effect PCOS creates hormonal resistance to weight loss interventions Cushing syndrome and other cortisol disorders override appetite suppression mechanisms Certain medications , including some antidepressants, antipsychotics, corticosteroids, and beta-blockers, promote weight gain through independent pathways If you have any of these conditions, semaglutide may still work but could require higher doses or additional interventions
It is also known to have positive effects on the immune system, gut health and muscle health
Medicaid coverage of GLP-1s for obesity, however, varies by state
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