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Spatial transcriptomics surrounding amyloid- plaques in a mouse model of AD indicates altered gene expression relating to oligodendrocytes and myelin

Eight more mutations (H18D, H21N, R167N, K168A, D171S, K172R, E174S, and I179T) were introduced at binding site 1 on the molecule to prevent PEGylation and to increase the affinity for the receptor at this site

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Thus, the meningococcus can regulate NF-B signaling, triggering its activation early in infection and then interrupting it